Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C

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Single-channel mechanosensitive currents.

Morris and Horn (1) describe ion channel activity, elicited by mechanical stimulation, in both membrane patches and in whole neurons from the snail Lymnaea stagnalis. In whole-cell recordings, mechanical stimulation did not elicit the large macroscopic mechanosensitive currents (IMs) that were anticipated from studies of single mechanosensitive (MS) channels in membrane patches. These negative ...

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Single-channel mechanosensitive currents.

Morris and Horn (1) describe ion channel activity, elicited by mechanical stimulation, in both membrane patches and in whole neurons from the snail Lymnaea stagnalis. In whole-cell recordings, mechanical stimulation did not elicit the large macroscopic mechanosensitive currents (IMs) that were anticipated from studies of single mechanosensitive (MS) channels in membrane patches. These negative ...

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Touch sensation or proprioception requires the transduction of mechanical stimuli into electrical signals by mechanoreceptors in the periphery. These mechanoreceptors are equipped with various transducer channels. Although Piezo1 and 2 are mechanically activated (MA) channels with rapid inactivation, MA molecules with other inactivation kinetics have not been identified. Here we report that het...

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ژورنال

عنوان ژورنال: Neuron

سال: 2017

ISSN: 0896-6273

DOI: 10.1016/j.neuron.2017.03.038