Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C
نویسندگان
چکیده
منابع مشابه
Single-channel mechanosensitive currents.
Morris and Horn (1) describe ion channel activity, elicited by mechanical stimulation, in both membrane patches and in whole neurons from the snail Lymnaea stagnalis. In whole-cell recordings, mechanical stimulation did not elicit the large macroscopic mechanosensitive currents (IMs) that were anticipated from studies of single mechanosensitive (MS) channels in membrane patches. These negative ...
متن کاملSingle-channel mechanosensitive currents.
Morris and Horn (1) describe ion channel activity, elicited by mechanical stimulation, in both membrane patches and in whole neurons from the snail Lymnaea stagnalis. In whole-cell recordings, mechanical stimulation did not elicit the large macroscopic mechanosensitive currents (IMs) that were anticipated from studies of single mechanosensitive (MS) channels in membrane patches. These negative ...
متن کاملTentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function
Touch sensation or proprioception requires the transduction of mechanical stimuli into electrical signals by mechanoreceptors in the periphery. These mechanoreceptors are equipped with various transducer channels. Although Piezo1 and 2 are mechanically activated (MA) channels with rapid inactivation, MA molecules with other inactivation kinetics have not been identified. Here we report that het...
متن کاملMechanosensitive channel of large conductance.
Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During t...
متن کاملTwo families of mechanosensitive channel proteins.
Mechanosensitive (MS) channels that provide protection against hypoosmotic shock are found in the membranes of organisms from the three domains of life: bacteria, archaea, and eucarya. Two families of ubiquitous MS channels are recognized, and these have been designated the MscL and MscS families. A high-resolution X-ray crystallographic structure is available for a member of the MscL family, a...
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ژورنال
عنوان ژورنال: Neuron
سال: 2017
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.03.038